• DOI:10.1007/s00439-005-0119-4
Corpus ID: 1370892

Extreme skewing of X chromosome inactivation in mothers of homosexual men

@article{Bocklandt2005ExtremeSO,
  title={Extreme skewing of X chromosome inactivation in mothers of homosexual men},
  author={S. Bocklandt and S. Horvath and E. Vilain and Dean H. Hamer},
  journal={Human Genetics},
  year={2005},
  volume={118},
  pages={691-694}
}

S. Bocklandt, S. Horvath, +1 author Dean H. Hamer

Published 2005

Biology, Medicine

Human Genetics

Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in… CONTINUE READING

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