Extreme skewing of X chromosome inactivation in mothers of homosexual men

  title={Extreme skewing of X chromosome inactivation in mothers of homosexual men},
  author={S. Bocklandt and S. Horvath and E. Vilain and Dean H. Hamer},
  journal={Human Genetics},
  • S. Bocklandt, S. Horvath, +1 author Dean H. Hamer
  • Published 2005
  • Biology, Medicine
  • Human Genetics
  • Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in… CONTINUE READING
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