Extreme obesity may be linked to markers flanking the human OB gene.

@article{Reed1996ExtremeOM,
  title={Extreme obesity may be linked to markers flanking the human OB gene.},
  author={Danielle R Reed and Yu Ding and Wen Xu and Corrine Cather and Eric D. Green and Robert A. Price},
  journal={Diabetes},
  year={1996},
  volume={45 5},
  pages={691-4}
}
Mice with mutations of the ob gene are extremely obese, and the human homologue (OB) has been cloned and physically mapped. The protein product of the ob gene (leptin) reduces body fat in mice when given exogenously, and leptin has been proposed to provide a lipostatic signal that regulates adiposity. Variation in the OB gene may be one genetically determined cause of obesity in human populations. To test this hypothesis, we genotyped siblings from 78 families at markers flanking the human OB… CONTINUE READING