Extreme multifunctional proteins identified from a human protein interaction network

@inproceedings{Chapple2015ExtremeMP,
  title={Extreme multifunctional proteins identified from a human protein interaction network},
  author={Charles E. Chapple and Benoit Robisson and Lionel Spinelli and C{\'e}line Guien and Emmanuelle Becker and Christine Brun},
  booktitle={Nature communications},
  year={2015}
}
Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we… CONTINUE READING
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