Extreme methaemoglobinaemia secondary to recreational use of amyl nitrite.

  title={Extreme methaemoglobinaemia secondary to recreational use of amyl nitrite.},
  author={Richard J. Edwards and Josef Ujma},
  journal={Journal of accident & emergency medicine},
  volume={12 2},
Haemoglobin is continuously oxidized from the ferrous (Fe2+) to the ferric (Fe3+) form and reduced back again. The ferric (Fe3+) form, termed methaemoglobin (MetHb), is incapable of transporting oxygen. In the normal physiological state the concentration of methaemoglobin is less than 1 %. Figure 1 illustrates the physiological reactions responsible for the reduction of MetHb back to Hb. It is reported that MetHb levels of 1025% produce cyanosis, 35-40% produce mild symptoms (e.g. dyspnoea… CONTINUE READING
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Clinical Haematology, 7th edition

  • M. M. Wintrobe, G. R. Less, l.R Boggs
  • Lea & Febiger, Philadelphia
  • 1974
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