Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity.

@article{Semple1999ExtremeLO,
  title={Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity.},
  author={John W Semple and Edwin R Speck and D Cosgrave and Alan H Lazarus and Victor S. Blanchette and John T. Freedman},
  journal={Blood},
  year={1999},
  volume={93 2},
  pages={713-20}
}
In a murine model of platelet alloimmunization, we examined the definitive role that mononuclear cells (MC) have in modulating platelet immunity by using platelets from severe combined immunodeficient (SCID) mice. CB.17 (H-2(d)) SCID or BALB/c (H-2(d)) mouse platelets were transfused weekly into fully allogeneic CBA (H-2(k)) mice and antidonor antibodies measured by flow cytometry. MC levels in BALB/c platelets were 1.1 +/- 0.6/microL and SCID mouse platelets could be prepared to have… CONTINUE READING

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