Extreme genomic variation in a natural population.

  title={Extreme genomic variation in a natural population.},
  author={Kerrin Small and Michael Brudno and Matthew L. Hill and Arend Sidow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 13},
Whole-genome sequence data from samples of natural populations provide fertile grounds for analyses of intraspecific variation and tests of population genetic theory. We show that the urochordate Ciona savignyi, one of the species of ocean-dwelling broadcast spawners commonly known as sea squirts, exhibits the highest rates of single-nucleotide and structural polymorphism ever comprehensively quantified in a multicellular organism. We demonstrate that the cause for the extreme heterozygosity is… CONTINUE READING
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