Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder.

@article{Garbarino2019ExtremeEO,
  title={Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder.},
  author={Valentina R. Garbarino and T Lee Gilman and Lynette C. Daws and Georgianna G Gould},
  journal={Pharmacological research},
  year={2019},
  volume={140},
  pages={
          85-99
        }
}
A variety of human and animal studies support the hypothesis that serotonin (5-hydroxytryptamine or 5-HT) system dysfunction is a contributing factor to the development of autism in some patients. However, many questions remain about how developmental manipulation of various components that influence 5-HT signaling (5-HT synthesis, transport, metabolism) persistently impair social behaviors. This review will summarize key aspects of central 5-HT function important for normal brain development… CONTINUE READING
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