Extreme Dynamics in the BamA β-Barrel Seam.

  title={Extreme Dynamics in the BamA β-Barrel Seam.},
  author={Pamela Arden Doerner and Marcelo C Sousa},
  volume={56 24},
BamA is an essential component of the β-barrel assembly machine (BAM) that is responsible for insertion and folding of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. BamA is an OMP itself, and its β-barrel transmembrane domain is thought to catalyze OMP insertion and folding, although the molecular mechanism remains poorly understood. Crystal structures of BamA and complementary molecular dynamics simulations have shown that its β-barrel seam (the interface between the first… CONTINUE READING


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