Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans

@inproceedings{Pyle2015ExtremeDepthRO,
  title={Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans},
  author={Angela Pyle and Gavin Hudson and Ian J. Wilson and Jonathan Coxhead and Tania Smertenko and Mary Herbert and Mauro F. Santibanez-Koref and Patrick F. Chinnery},
  booktitle={PLoS genetics},
  year={2015}
}
Recent reports have questioned the accepted dogma that mammalian mitochondrial DNA (mtDNA) is strictly maternally inherited. In humans, the argument hinges on detecting a signature of inter-molecular recombination in mtDNA sequences sampled at the population level, inferring a paternal source for the mixed haplotypes. However, interpreting these data is fraught with difficulty, and direct experimental evidence is lacking. Using extreme-high depth mtDNA re-sequencing up to ~1.2 million-fold… CONTINUE READING
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