Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants

@inproceedings{Bharill2013ExtremeDO,
  title={Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants},
  author={Puneet Bharill and Srinivas Ayyadevara and Ramani Alla and Robert J Shmookler Reis},
  booktitle={Front. Genet.},
  year={2013}
}
The regulation of animal longevity shows remarkable plasticity, in that a variety of genetic lesions are able to extend lifespan by as much as 10-fold. Such studies have implicated several key signaling pathways that must normally limit longevity, since their disruption prolongs life. Little is known, however, about the proximal effectors of aging on which these pathways are presumed to converge, and to date, no pharmacologic agents even approach the life-extending effects of genetic mutation… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
6 Citations
53 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Quantitative trait loci define genes and pathways underlying genetic variation in longevity

  • R. J. Shmookler Reis, P. Kang, S. Ayyadevara
  • Exp. Gerontol
  • 2007
Highly Influential
5 Excerpts

Methods,” in The Nematode Caenorhabditis elegans, ed

  • J. Sulston, J. Hodgkin
  • NY: Cold Spring Harbor Laboratory
  • 1988
Highly Influential
4 Excerpts

Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans

  • S. Ayyadevara, R. Ayyadevera, S. Hou, J. J. Thaden, R. J. Shmookler Reis
  • 2001
Highly Influential
1 Excerpt

Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant - inbred progeny of a Bergerac - BO × RC 301 interstrain cross

  • S. Ayyadevara, R. Ayyadevera, S. Hou, J. J. Thaden, R. J. Shmookler Reis
  • Genetics
  • 2001
Highly Influential
1 Excerpt

“ Methods , ”

  • J. Sulston, J. Hodgkin
  • The Nematode Caenorhabditis elegans
  • 1988
Highly Influential
3 Excerpts

Extreme depletion of PIP3 accompanies the increased life span and stress tolerance of PI3K-null C

  • P Citation Bharill, S Ayyadevara, R Alla, RJ Shmookler Reis
  • 2013

Frontiers in Genetics of Aging, a specialty of Frontiers in Genetics

  • Bharill, Ayyadevara, Alla, Shmookler Reis
  • 2013

Similar Papers

Loading similar papers…