Extreme, progressive isovolemic hemodilution with 5% human albumin, PentaLyte, or Hextend does not cause hepatic ischemia or histologic injury in rabbits.

@article{Nielsen1999ExtremePI,
  title={Extreme, progressive isovolemic hemodilution with 5% human albumin, PentaLyte, or Hextend does not cause hepatic ischemia or histologic injury in rabbits.},
  author={Vance G. Nielsen and Manuel S. Baird and Amy E. Brix and Sadis Matalon},
  journal={Anesthesiology},
  year={1999},
  volume={90 5},
  pages={
          1428-35
        }
}
BACKGROUND Physicians and their patients are greatly concerned about perioperative blood administration. Although isovolemic hemodilution is utilized to decrease the incidence of transfusion, it is unclear at what degree of hemodilution hepatoenteric ischemia and injury occurs. The authors hypothesized that hepatic ischemia, systemic ischemia, and tissue injury would occur during hemodilution in rabbits, and that the severity of ischemia and injury may be dependent on the fluid administered… CONTINUE READING
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