Extravasation of blood-borne immunoglobulin G through blood-brain barrier during adrenaline-induced transient hypertension in the rat.

@article{Kuang2004ExtravasationOB,
  title={Extravasation of blood-borne immunoglobulin G through blood-brain barrier during adrenaline-induced transient hypertension in the rat.},
  author={F. C. Kuang and Bai-ren Wang and Ping Zhang and Ling-Ling Fei and Y. C. Jia and Xiao-li Duan and Xi Wang and Zhen Xu and Gai-li Li and Xi-ying Jiao and Gong Ju},
  journal={The International journal of neuroscience},
  year={2004},
  volume={114 6},
  pages={575-91}
}
The effect of transient hypertension on blood-brain barrier (BBB) permeability, particularly on extravasation of immunoglobulin G (IgG), has not been fully understood. In the present experiment, we investigated the time course of endogenous albumin and IgG extravasation through BBB and the localization of extravasated IgG in brain parenchyma during adrenaline(AD)-induced transient hypertension in the rat by using Evans blue fluorescence, immunohistochemistry, and Western blot. The results… CONTINUE READING

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