Extrathymically generated regulatory T cells control mucosal TH2 inflammation

@article{Josefowicz2012ExtrathymicallyGR,
  title={Extrathymically generated regulatory T cells control mucosal TH2 inflammation},
  author={Steven Z. Josefowicz and Rachel E. Niec and Hye Young Kim and Piper R. Treuting and Takatoshi Chinen and Ye Zheng and Dale T. Umetsu and Alexander Y Rudensky},
  journal={Nature},
  year={2012},
  volume={482},
  pages={395-399}
}
A balance between pro- and anti-inflammatory mechanisms at mucosal interfaces, which are sites of constitutive exposure to microbes and non-microbial foreign substances, allows for efficient protection against pathogens yet prevents adverse inflammatory responses associated with allergy, asthma and intestinal inflammation. Regulatory T (Treg) cells prevent systemic and tissue-specific autoimmunity and inflammatory lesions at mucosal interfaces. These cells are generated in the thymus (tTreg… CONTINUE READING
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