Extrathymic pathways of T-cell differentiation and immunomodulation.

  title={Extrathymic pathways of T-cell differentiation and immunomodulation.},
  author={Toru Abo},
  journal={International immunopharmacology},
  volume={1 7},
  • Toru Abo
  • Published 2001 in International immunopharmacology
It is well established that the thymus is an essential organ for the support of T-cell differentiation. However, some T cells, termed extrathymic T cells, have been found to differentiate without such support by the thymus. The major sites of these T cells are the intestine and liver. Subsequent studies have revealed that extrathymic T cells are also present in the uterus and exocrine glands (e.g., the salivary gland). Depending on the sites, extrathymic T cells have some distinct properties as… CONTINUE READING


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