Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

@article{Hardingham2002ExtrasynapticNO,
  title={Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways},
  author={G. Hardingham and Y. Fukunaga and H. Bading},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={405-414}
}
Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene expression as strongly as did stimulation of L-type calcium channels. In contrast, calcium entry through extrasynaptic NMDA receptors, triggered by bath glutamate exposure or… Expand
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