Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.

@article{Vanini2013ExtrasynapticGR,
  title={Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.},
  author={Giancarlo Vanini and Helen A Baghdoyan},
  journal={Sleep},
  year={2013},
  volume={36 3},
  pages={337-43}
}
STUDY OBJECTIVES Gamma-aminobutyric acid (GABA) causes phasic inhibition via synaptic GABAA receptors and tonic inhibition via extrasynaptic GABAA receptors. GABA levels in the extracellular space regulate arousal state and cognition by volume transmission via extrasynaptic GABAA receptors. GABAergic transmission in the pontine reticular formation promotes wakefulness. No previous studies have determined whether an agonist at extrasynaptic GABAA receptors administered into the pontine reticular… CONTINUE READING

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