• DOI:10.1097/EJA.0000000000000048
Corpus ID: 36545119

Extrapyramidal symptoms following administration of oral perphenazine 4 or 8 mg: An 11-year retrospective analysis

@article{Henao2014ExtrapyramidalSF,
  title={Extrapyramidal symptoms following administration of oral perphenazine 4 or 8 mg: An 11-year retrospective analysis},
  author={J. Henao and K. Peperzak and A. Lichvar and S. Orebaugh and S. Skledar and Michael A Pippi and B. Williams},
  journal={European Journal of Anaesthesiology},
  year={2014},
  volume={31},
  pages={231–235}
}

J. Henao, K. Peperzak, +4 authors B. Williams

Published 2014

Medicine

European Journal of Anaesthesiology

BACKGROUND Perphenazine is a treatment option in postoperative nausea and vomiting (PONV) prophylaxis. Chronic administration and high dose are known to cause extrapyramidal system (EPS) dysfunction at a frequency of 8%, but the incidence of acute EPS after a single 4 or 8 mg dose is unknown. OBJECTIVE A retrospective analysis of patient medication billing data and departmental quality records was performed (January 2001 to 10 July 2012) to identify patients who experienced EPS dysfunction… CONTINUE READING

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