Extrapulmonary effects of nitric oxide inhalation therapy: time to consider new dosing regimes?

Abstract

Studies with nitric oxide (NO) inhalation suggest transformation of NO in the lung into a more long-lived bioactive NO species that also has distal effects [1,2]. The exact nature of these species has not been pinpointed, but probable candidates include circulating nitrite anions and/or S-nitrosothiols [3]. When using inhaled NO therapeutically for… (More)
DOI: 10.1186/cc6775

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