Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus

@article{Soundararajan2009ExtrapolatingFS,
  title={Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus},
  author={V. Soundararajan and Kannan Tharakaraman and R. Raman and S. Raguram and Z. Shriver and V. Sasisekharan and R. Sasisekharan},
  journal={Nature Biotechnology},
  year={2009},
  volume={27},
  pages={510-513}
}
The recent incidence and spread in humans of the 'swine flu' influenza A virus has raised global concerns regarding its virulence and pandemic potential. The main cause of the so-called swine flu has been identified as human infection by influenza A viruses of a new H1N1 (hemagglutinin 1, neuraminidase 1) subtype, or '2009 H1N1 strain'. 
Analysis of influenza A viruses of subtype H1 from wild birds, turkeys and pigs in Germany reveals interspecies transmission events
TLDR
Analysis of influenza A viruses of subtype H1 from wild birds, turkeys and pigs in Germany reveals interspecies transmission events. Expand
Que sera, sera: evolution of the swine H1N1 influenza A virus
A new human influenza A virus (IAV) strain of swine-like origin emerged in Mexico and the United States in March and April of 2009 [1]. The virus disseminated globally with sufficient celerity thatExpand
Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice
TLDR
Although results were variable, it seems that the 2009 A(H1N1) virus may be less efficiently transmitted by respiratory droplets in comparison to the highly transmissible seasonal H1n1 virus, suggesting that additional virus adaptation in mammals may be required before the authors see phenotypes observed in earlier pandemics. Expand
Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management
TLDR
Information generated from cell lines, animal models, and clinical data analysis has provided greater understanding of the behavior of this virus and the associated host response, and will allow us to formulate scientifically sound and evidence-based management plans. Expand
Influenza A viruses: new research developments
TLDR
The value of surveillance and characterization of naturally occurring influenza viruses are discussed, and the impact that new developments in the laboratory have had on the authors' understanding of the host tropism and virulence of viruses are reviewed. Expand
Reassortants of pandemic influenza A virus H1N1/2009 and endemic porcine HxN2 viruses emerge in swine populations in Germany.
TLDR
The incursion of the human pandemic influenza A virus H1N1 (2009) into pig populations and its ongoing co-circulation with endemic swine influenza viruses (SIVs) has yielded distinct human-porcine reassortant virus lineages, giving rise to reassortants with as-yet-unknown biological properties and undetermined risks for public health. Expand
Viral determinants of influenza A virus host range.
TLDR
The current understanding of the mechanisms by which influenza viruses adapt to replicate efficiently in a new host is reviewed, predominantly focus on the influenza polymerase, which remains one of the least understood host-range barriers. Expand
Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin
TLDR
The 3D-structure of the major surface viral antigen from the recent H1N1 pandemic influenza virus (A/Darwin/2001/2009) was determined and reveals a strict preference for human-type receptors. Expand
Phylogenetic Analysis of HA and NA Genes of Swine Influenza Viruses in Serbia in 2016-2018
TLDR
The objectives of this research were to determine the presence of the influenza A virus in nasal and tracheobronchial swabs and lung tissue samples of ill and dead pigs on commercial farms, to determine circulating subtypes and characterize them through the phylogenetic analysis of hemagglutinin (HA) and neuraminidase (NA) genes. Expand
A Single Amino Acid in the HA of pH1N1 2009 Influenza Virus Affects Cell Tropism in Human Airway Epithelium, but Not Transmission in Ferrets
TLDR
Investigation of the effect of residue 227 in HA on cell tropism and transmission of pH1N1 2009 finds this residue may alter the sialic acid conformer binding preference of the HA and alter the ability of the virus to transmit between humans. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings
TLDR
Transmissibility is substantially higher than that of seasonal flu, and comparable with lower estimates of R0 obtained from previous influenza pandemics, by analyzing the outbreak in Mexico, early data on international spread, and viral genetic diversity, which makes an early assessment of transmissibility and severity. Expand
Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus
TLDR
Reverse genetics was used to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence, and confirmed that the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemicirus. Expand
Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus
TLDR
The 1918 virus virulence observed in mice correlated with the ability of 1918 recombinant viruses to replicate efficiently in human airway cells, highlighting the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain. Expand
A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission
TLDR
These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals and suggest that a predominant human α-2,6 sialic acid binding preference is essential for optimal transmission of this pandemic virus. Expand
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
TLDR
It is demonstrated that the adaptation of the HA and PB2 proteins are critical for the development of pandemic influenza strains from avian influenza viruses. Expand
The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin
TLDR
The crystal structures of the HA from the 1918 virus and two closelyrelated HAs in complex with receptor analogs are determined, explaining how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how the virus was able to spread in the human population. Expand
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
TLDR
The enzymatic properties and crystal structures of neuraminidase mutants from H5N1-infected patients are reported that explain the molecular basis of resistance and indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivIR. Expand
Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses
TLDR
The dramatic lower binding affinity of NY18 to long α2-6 glycans, as against a mixedα2-3/6 binding, correlates with its inefficient transmission, and this study establishes a quantitative biochemical correlate for influenza A virus transmission. Expand
Characterization of the 1918 influenza virus polymerase genes
The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors, thereby having a role in hostExpand
Influenza A virus neuraminidase: regions of the protein potentially involved in virus-host interactions.
TLDR
Phylogenetically informative amino acid positions (PIPs) were identified in influenza A neuraminidases of subtypes N1 and N2, which represent additional antigenic sites or may be involved in other aspects of virus-host biology. Expand
...
1
2
...