Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma

  title={Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma},
  author={Kevin Lee Du and Stefan Both and Joseph S. Friedberg and Ramesh Rengan and Stephen M. Hahn and Keith A. Cengel},
  journal={Cancer Biology \& Therapy},
  pages={425 - 429}
Intensity modulated radiation therapy (IMRT) has recently been proposed for the treatment of malignant pleural mesothelioma (MPM). Here, we describe our experience with a multimodality approach for the treatment of mesothelioma, incorporating extrapleural pneumonectomy, intraoperative photodynamic therapy and postoperative hemithoracic IMRT. From 2004-2007, we treated 11 MPM patients with hemithoracic IMRT, 7 of whom had undergone porfimer sodium-mediated PDT as an intraoperative adjuvant to… 

Intensity-Modulated Radiotherapy After Extrapleural Pneumonectomy in the Combined-Modality Treatment of Malignant Pleural Mesothelioma

  • A. ChiZ. Liao R. Komaki
  • Medicine, Physics
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2011
The current evidence and indications for adjuvant intensity-modulated radiotherapy (IMRT), as well as how to further improve this technique and adapt new technology in the delivering adjUvant radiotherapy in the setting of trimodality therapy, are explored.

Photodynamic therapy for lung cancer and malignant pleural mesothelioma.

Intraoperative PDT can be safely combined with macroscopically complete surgical resection and other treatment modalities for malignant pleural mesothelioma (MPM) to improve local control and prolong survival.

Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies

The role of photodynamic therapy in thoracic malignancies continues to evolve, as new generation photosensitizers are being developed and tested and methodological issues continue to be addressed.

Modern Radiotherapy Techniques in Malignant Pleural Mesothelioma

Every patient with MPM should receive RT in the adjuvant setting, and more advanced technology has been shown to result in better target coverage with decreased rates of toxicity.

The Role of Adjuvant Radiotherapy in the Treatment of Pleural Mesothelioma

In the treatment of malignant pleural mesothelioma, adjuvant radiotherapy after surgical intervention was associated with improved OS.

Intensity modulated radiation therapy after extra‐pleural pneumonectomy for malignant pleural mesothelioma is feasible without fatal pulmonary toxicity and provides good survival

To analyze patterns of failure, toxicity, relapse‐free survival (RFS), and overall survival (OS) in malignant pleural mesothelioma (MPM) patients treated with intensity‐modulated radiation therapy

Dosimetric evaluation of helical tomotherapy and volumetric-modulated arc therapy for malignant pleural mesothelioma: a planning study for dose escalation

Compared to the VMAT plans, the HT plans not only demonstrated more optimal target coverage and conformity but also considerably reduced the dose-volume parameters of the OARs in both low-dose areas in contralateral lung and high-dose Areas in ipsilateral lung and contral lateral lung, which is correlated to radiation injury.

Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma.

Electroporation in a mouse mesothelioma xenograft was able to facilitate the expression of exogenous HtrA1 injected intra-lesionally in the tumors and to increase the penetration in the neoplastic cells of cisplatin given intra-peritoneally.



Intensity-modulated radiotherapy following extrapleural pneumonectomy for the treatment of malignant mesothelioma: clinical implementation.

Hemithoracic radiation after extrapleural pneumonectomy for malignant pleural mesothelioma.

Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma.

Intensity-modulated radiation therapy: a novel approach to the management of malignant pleural mesothelioma.

Patterns of failure after trimodality therapy for malignant pleural mesothelioma.

Intensity-modulated radiotherapy for resected mesothelioma: the Duke experience.

A phase I study of Foscan-mediated photodynamic therapy and surgery in patients with mesothelioma.

Dose-dependent pulmonary toxicity after postoperative intensity-modulated radiotherapy for malignant pleural mesothelioma.

Phase II trial of pleural photodynamic therapy and surgery for patients with non-small-cell lung cancer with pleural spread.

  • J. FriedbergR. Mick S. Hahn
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2004
The results indicate surgery and PDT can be performed safely with very good local control and survival of combining surgery with intraoperative photodynamic therapy (PDT), a light-based cancer treatment, in patients with NSCLC with pleural spread.