Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

@article{Venegas2012ExtrapinealMA,
  title={Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations},
  author={Carmen Venegas and Jos{\'e} A. Garc{\'i}a and Germaine Escames and Francisco Ortiz and Ana L{\'o}pez and Carolina Doerrier and Laura Garc{\'i}a-Corzo and Luis Carlos L{\'o}pez and Russel Joseph Reiter and Dar{\'i}o Acu{\~n}a-Castroviejo},
  journal={Journal of Pineal Research},
  year={2012},
  volume={52}
}
Abstract:  We studied the subcellular levels of melatonin in cerebral cortex and liver of rats under several conditions. The results show that melatonin levels in the cell membrane, cytosol, nucleus, and mitochondrion vary over a 24‐hr cycle, although these variations do not exhibit circadian rhythms. The cell membrane has the highest concentration of melatonin followed by mitochondria, nucleus, and cytosol. Pinealectomy significantly increased the content of melatonin in all subcellular… 
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