Extrapancreatic effect of somatostatin infusion to increase glucose clearance.

  title={Extrapancreatic effect of somatostatin infusion to increase glucose clearance.},
  author={Richard N Bergman and Marilyn Ader and Diane T. Finegood and Giovanni Pacini},
  journal={The American journal of physiology},
  volume={247 3 Pt 1},
Constant intraportal insulin, coupled with variable intraportal glucagon, was used in the attempt to reestablish basal metabolic conditions in dogs during somatostatin (SRIF) infusion (0.8 micrograms X min-1 X kg-1). SRIF alone lowered glucose (G), insulin (I), and glucagon (GN) (G: 90 +/- 5 to 69 +/- 1 mg/dl; I: 18 +/- 4 to 4 +/- 1 microU/ml; GN: 257 +/- 52 to 168 +/- 40 pg/ml; P less than 0.05 or better). Hormone replacement. Hypoglycemia persisted (G at steady state, SS, 60-150 min): 12… CONTINUE READING

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