Extraordinary neoteny of synaptic spines in the human prefrontal cortex.

Abstract

The major mechanism for generating diversity of neuronal connections beyond their genetic determination is the activity-dependent stabilization and selective elimination of the initially overproduced synapses [Changeux JP, Danchin A (1976) Nature 264:705-712]. The largest number of supranumerary synapses has been recorded in the cerebral cortex of human and… (More)
DOI: 10.1073/pnas.1105108108

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