Extraocular muscle force generation after ricin-mAb35 injection: implications for strabismus treatment.

@article{Christiansen2003ExtraocularMF,
  title={Extraocular muscle force generation after ricin-mAb35 injection: implications for strabismus treatment.},
  author={Stephen P. Christiansen and Bryan Becker and Paul Anthony Iaizzo and Linda K McLoon},
  journal={Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus},
  year={2003},
  volume={7 1},
  pages={1-6}
}
PURPOSE Ricin-mAb35 is an immunotoxin targeted against skeletal muscle. Previously, we have shown that injection of ricin-mAb35 into rabbit extraocular muscle results in long-term muscle loss, and we have proposed this as a potential treatment for strabismus. In this study, we assessed the effects of ricin-mAb35 injection on extraocular muscle force generation. METHODS Ricin-mAb35, 0.2 microg/kg in a volume of 0.1 mL, was injected into 1 superior rectus muscle in 16 adult rabbits. The… CONTINUE READING
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