Extranodal extension of nodal metastases is a poor prognostic moderator in non-small cell lung cancer: a meta-analysis

@article{Luchini2018ExtranodalEO,
  title={Extranodal extension of nodal metastases is a poor prognostic moderator in non-small cell lung cancer: a meta-analysis},
  author={Claudio Luchini and Nicola Veronese and Alessia Nottegar and Monica Cheng and Takuma Kaneko and Camilla Pilati and Fabrizio Tabb{\'o} and Brendon Stubbs and Antonio Pea and Fabio Bagante and Jacopo Demurtas and Matteo Fassan and Maurizio Valentino Infante and Liang Cheng and Aldo Scarpa},
  journal={Virchows Archiv},
  year={2018},
  volume={472},
  pages={939-947}
}
Extranodal extension (ENE) of nodal metastasis is defined as the extension of metastatic cells through the nodal capsule into the perinodal tissue. This morphological parameter, recently proposed as an important prognostic factor in different types of malignancy, has not been included in the TNM staging system for non-small cell lung cancer (NSCLC). In this systematic review with meta-analysis, we weighted the prognostic role of ENE in patients with lymph node-positive NSCLC. Two independent… CONTINUE READING
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