Extranodal NK/T-cell lymphoma: Updates in biology and management strategies.

@article{Yamaguchi2018ExtranodalNL,
  title={Extranodal NK/T-cell lymphoma: Updates in biology and management strategies.},
  author={Motoko Yamaguchi and Masahiko Oguchi and Ritsuro Suzuki},
  journal={Best practice \& research. Clinical haematology},
  year={2018},
  volume={31 3},
  pages={
          315-321
        }
}
Extranodal NK/T cell lymphoma, nasal type: an updated overview.
Nodal and extranodal peripheral T/NK-cell neoplasms: Current aspects
TLDR
There has been evidence – based improvement in the treatment paradigm by the introduction of L–Asparaginase and targeted therapy for CD30+ PTCL and a considerable number of new compounds entered early phase trials and gave promising results.
Extranodal T/NK Lymphomas
  • S. Novelli
  • Medicine, Biology
    Peripheral T-cell Lymphomas
  • 2019
TLDR
As the only potentially curative therapy is allogeneic hematopoietic stem cell transplantation, it should be assessed in relapsing/ refractory NK/T lymphoma nasal type and in the first line after remission in the other extranodal NK-T lymphomas.
Extranodal NK/T-cell lymphoma in Tunisia: clinicopathological features, immunophenotype and EBV infection
TLDR
A careful histopathological examination combined with a correct interpretation of immunohistochemistry and in situ hybridization results refines the ENKTL diagnosis.
Extranodal NK/T-Cell Lymphoma With Widespread Cutaneous and Subcutaneous Involvement on 18F-FDG PET/CT.
TLDR
A unique case of extranodal natural killer/T-cell lymphoma with widespread cutaneous and subcutaneous involvement on 18F-FDG PET/CT is presented.
Metabolic activity of extranodal NK/T cell lymphoma on 18F-FDG PET/CT according to immune subtyping
TLDR
It is demonstrated that FDG PET/CT can help predict immune subtype in ENKTL patients and the different patterns between glycolytic activity and involved site according to TIME subtype might be related to the interplay between tumor cells and immune cells in the tumor microenvironment.
Extranodal NK/T Cell Lymphoma, Nasal Type with Palatal Involvement: A Rare Case Report and Literature Review
TLDR
A case of a 76-year-old Greek man with nasal obstruction and an extensive painful necrotic ulcer with ragged borders on the left distal portion of the soft palate and palatine tonsil of 4-months duration is described.
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References

SHOWING 1-10 OF 88 REFERENCES
Current treatment approaches for NK/T-cell lymphoma.
TLDR
This review will summarize the current management of ENKL, primarily based on clinical trial results, and provide clues for better future management.
Extranodal NK/T-Cell Lymphoma: Toward the Identification of Clinical Molecular Targets
TLDR
Some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies are reviewed.
Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type.
TLDR
Accumulating evidence supports the use of sequential chemoradiotherapy with non-anthracycline-containing regimens that include l-asparaginase and/or platinum anticancer agents for systemic ENKL.
The diagnosis and management of NK/T-cell lymphomas
TLDR
In relapsed/refractory cases, blockade of the programmed death protein 1 has recently shown promising results with high response rates, and autologous haematopoietic stem cell transplantation has not been shown to be beneficial.
NK/T Cell Lymphoma: Updates in Therapy
  • R. Suzuki
  • Medicine, Biology
    Current Hematologic Malignancy Reports
  • 2018
TLDR
The prognosis of ENKL is improving by the introduction of anti-PD-1 or other immunological checkpoint inhibitors thought to be due to EBV-driven upregulation of PD-L1 expression, and there still exists a room for improvement, particularly for advanced-stage patients.
Molecular underpinning of extranodal NK/T-cell lymphoma.
Emerging insights on the pathogenesis and treatment of extranodal NK/T cell lymphomas (ENKTL).
TLDR
A number of recent discoveries including disturbances in cell signaling and mutations in tumor suppressor genes have been identified, providing insights into the pathogenesis of ENKTL, and potential therapeutic implications are discussed.
Encouraging experience in the treatment of nasal type extra-nodal NK/T-cell lymphoma in a non-Asian population
TLDR
EN-NK/TCL-NT in non-Asians shared similar disease characteristics and treatment outcomes with Asians, and management of advanced-stage disease remains challenging, with frequent progression and high mortality.
Extranodal natural killer/T-cell lymphoma from skin or soft tissue: suggestion of treatment from multinational retrospective analysis.
  • H. Ahn, C. Suh, W. Kim
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2012
TLDR
The prognostic value of KPI is identified and a treatment recommendation according to the TNM (tumour-node-metastasis) stage is suggested, and Radiotherapy with/without chemotherapy seemed to be optimal in localized disease.
Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study.
  • Jeeyun Lee, C. Suh, W. Kim
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
TLDR
The newly proposed model for extranodal NK/T-cell lymphoma demonstrated a more balanced distribution of patients into four groups with better prognostic discrimination as compared with the International Prognostic Index.
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