Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogeneic hematopoietic cell transplantation.

@article{Kim2014ExtramedullaryRF,
  title={Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogeneic hematopoietic cell transplantation.},
  author={Ji Hyun Kim and Anthony S. Stein and Nicole Tsai and Timothy E. Schultheiss and Joycelynne Palmer and An Liu and Joseph Rosenthal and Stephen J. Forman and Jeffrey Y. C. Wong},
  journal={International journal of radiation oncology, biology, physics},
  year={2014},
  volume={89 1},
  pages={75-81}
}
PURPOSE Approximately 5% to 20% of patients who undergo total body irradiation (TBI) in preparation for hematopoietic cell transplantation (HCT) can develop extramedullary (EM) relapse. Whereas total marrow and lymphoid irradiation (TMLI) provides a more conformally targeted radiation therapy for patients, organ sparing has the potential to place the patient at a higher risk for EM relapse than TBI. This study evaluated EM relapse in patients treated with TMLI at our institution. METHODS AND… CONTINUE READING