Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals.

@article{Johns2012ExtramedullaryHA,
  title={Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals.},
  author={Jennifer L. Johns and M. S. M. Christopher},
  journal={Veterinary pathology},
  year={2012},
  volume={49 3},
  pages={508-23}
}
Extramedullary hematopoiesis (EMH) is the formation and development of blood cells outside the medullary spaces of the bone marrow. Although widely considered an epiphenomenon, secondary to underlying primary disease and lacking serious clinical or diagnostic implications, the presence of EMH is far from incidental on a molecular basis; rather, it reflects a well-choreographed suite of changes involving stem cells and their microenvironment (the stem cell niche). The goals of this review are to… CONTINUE READING
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