Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008.

@article{Ganzel2016ExtramedullaryDI,
  title={Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008.},
  author={Chezi Ganzel and Judith B. Manola and Dan Douer and Jacob M. Rowe and Hugo F Fernandez and Elisabeth Paietta and Mark R Litzow and J. W. Lee and Selina M. Luger and Hillard M Lazarus and Larry Dean Cripe and Peter H. Wiernik and Martin S. Tallman},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2016},
  volume={34 29},
  pages={
          3544-3553
        }
}
Purpose Extramedullary disease (EMD) at diagnosis in patients with acute myeloid leukemia (AML) has been recognized for decades. Reported herein are results from a large study of patients with AML who were treated in consecutive ECOG-ACRIN Cancer Research Group frontline clinical trials in an attempt to define the incidence and clinical implications of EMD. Methods Patients with newly diagnosed AML, age 15 years and older, who were treated in 11 clinical trials, were studied to identify EMD, as… CONTINUE READING
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