Extramedullary BCR-ABL1-negative myeloid leukemia in a patient with chronic myeloid leukemia and synchronous cytogenetic abnormalities in Philadelphia-positive and -negative clones during imatinib therapy

@article{QuintsCardama2007ExtramedullaryBM,
  title={Extramedullary BCR-ABL1-negative myeloid leukemia in a patient with chronic myeloid leukemia and synchronous cytogenetic abnormalities in Philadelphia-positive and -negative clones during imatinib therapy},
  author={Alfonso Quint{\'a}s-Cardama and H M Kantarjian and Lynne V. Abruzzo and J. C. Gal{\'a}n Cort{\'e}s},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={2394-2396}
}
In the majority of patients with chronic myelogenous leukemia (CML), the Philadelphia chromosome (Phþ ), t(9;22)(q34;q11.2), can be identified easily by conventional cytogenetic analysis of bone marrow specimens. The development of additional chromosomal abnormalities in Ph-positive metaphases, or ‘clonal evolution’, reflects the genetic instability… CONTINUE READING