Extraintestinal manifestations of coeliac disease

@article{Leffler2015ExtraintestinalMO,
  title={Extraintestinal manifestations of coeliac disease},
  author={Daniel A. Leffler and Peter H. R. Green and Alessio Fasano},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2015},
  volume={12},
  pages={561-571}
}
Coeliac disease is a common disorder that can arise at any age and typically presents with a broad spectrum of symptoms. The disease is thought to be underdiagnosed, in part owing to the fact that coeliac disease is often characterized by associated conditions and extraintestinal manifestations that can misdirect and impede diagnosis. Some of these manifestations are direct consequences of autoimmunity, such as dermatitis herpetiformis or gluten ataxia, whereas others are indirectly related to… 
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References

SHOWING 1-10 OF 227 REFERENCES
Endocrine Aspects of Coeliac Disease
TLDR
The literature on endocrine aspects of CD is reviewed, because patients with CD are at great risk of developing endocrine disorders.
Oral manifestations of celiac disease: a clinical guide for dentists.
TLDR
Dentists can play an important role in identifying people who may have unrecognized celiac disease, and Appropriate referral and a timely diagnosis can help prevent serious complications of this disorder.
Celiac sprue (the great modern-day imposter)
TLDR
The heterogeneity of the symptoms can make the diagnosis challenging and certainly the great modern-day imposter makes celiac disease the great today's imposter.
Hematologic manifestations of celiac disease.
TLDR
Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type, and the risk is highest for enteropathy-type T- cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen.
Mechanisms underlying celiac disease and its neurologic manifestations
TLDR
The authors review the cellular and molecular mechanisms behind the histopathologic changes in the intestine, discuss the presentation and characteristics of neurologic manifestations of CD, and review the data on the mechanisms behind these manifestations.
Celiac Disease: an Underappreciated Issue in Women's Health
TLDR
Increased awareness of the clinical spectrum of this disease, as well as targeted testing in at-risk individuals (including women with unexplained infertility and previous adverse pregnancy outcomes, and in specific populations with reduced BMD) is greatly needed in order to improve rates of diagnosis.
The arthritis of coeliac disease: prevalence and pattern in 200 adult patients.
TLDR
The data suggest that arthritis is much more common than previous reports have indicated, particularly in patients receiving an appropriate dietary regimen, and support the need for combined gastrointestinal and rheumatological follow-up in coeliac patients.
Oral Manifestations of Celiac Disease
TLDR
Patients with systematic dental enamel defects should be screened for CD even in the absence of gastrointestinal symptoms, and screening tests for patients with oral aphthae or idiopathic atrophic glossitis should be selectively considered during a medical evaluation that focuses on all aspects of the patient's status.
New Clues in Celiac Disease Epidemiology, Pathogenesis, Clinical Manifestations, and Treatment
TLDR
Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals, showing features of both an innate and an adaptive response to gluten prolamins.
Epidemiology and clinical presentations of celiac disease
TLDR
Serological screening studies have revealed that celiac disease is common, occurring in about 1 % of the population worldwide, and is found in most continents and appears to be increasing.
...
...