Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy.

@article{Bonilha2010ExtrahippocampalGM,
  title={Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy.},
  author={Leonardo Bonilha and Jonathan C. Edwards and Stephen L. Kinsman and Paul Simon Morgan and Julius Fridriksson and Chris Rorden and Zoran Rumboldt and Donna R Roberts and Mark A. Eckert and Jonathan J. Halford},
  journal={Epilepsia},
  year={2010},
  volume={51 4},
  pages={519-28}
}
PURPOSE Medial temporal epilepsy (MTLE) is associated with extrahippocampal brain atrophy. The mechanisms underlying brain damage in MTLE are unknown. Seizures may lead to neuronal damage, but another possible explanation is deafferentation from loss of hippocampal connections. This study aimed to investigate the relationship between hippocampal deafferentation and brain atrophy in MTLE. METHODS Three different MRI studies were performed involving 23 patients with unilateral MTLE (8 left and… CONTINUE READING

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