Extrahepatic manifestations in transgenic mice of osteopontin in hepatocytes-A clue to advent of pathological state in various organs of chronic hepatitis C patients.

Abstract

Osteopontin is a cytokine essential for initiation of Th1 immune reaction. We established transgenic mice expressing osteopontin in hepatocyte, in which liver necrosis with lymphocyte infiltration developed gradually from 12 weeks of age with up-regulated osteopontin levels in the circulation, suggesting that extrahepatic manifestations might also occur as… (More)

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@article{Saitoh2005ExtrahepaticMI, title={Extrahepatic manifestations in transgenic mice of osteopontin in hepatocytes-A clue to advent of pathological state in various organs of chronic hepatitis C patients.}, author={Eiko Saitoh and Atsushi Matsui and Mie Inao and Sumie Mimura and Heasaeng Koh and Akihiko Ohno and Sumiko Nagoshi and Hidekazu Kayano and Takayuki Yoshimoto and Satoshi Mochida and Kenji Fujiwara}, journal={Hepatology research : the official journal of the Japan Society of Hepatology}, year={2005}, volume={31 4}, pages={197-202} }