Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development.


SUMO-specific protease 2 (SENP2) activities to remove SUMO from its substrates is essential for development of trophoblast stem cells, niches and lineages. Global deletion of SENP2 leads to midgestation lethality, and causes severe defects in the placenta which is accompanied by embryonic brain and heart abnormalities. Because of the placental deficiencies… (More)
DOI: 10.1038/srep20999


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