Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.

@article{Akbari2009ExtractsOP,
  title={Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.},
  author={Mansour Akbari and Javier Peňa-Diaz and Sonja Andersen and N B Liabakk and Marit Otterlei and Hans Einar Krokan},
  journal={DNA repair},
  year={2009},
  volume={8 7},
  pages={834-43}
}
Base excision repair (BER) of damaged or inappropriate bases in DNA has been reported to take place by single nucleotide insertion or through incorporation of several nucleotides, termed short-patch and long-patch repair, respectively. We found that extracts from proliferating and non-proliferating cells both had capacity for single- and two-nucleotide insertion BER activity. However, patch size longer than two nucleotides was only detected in extracts from proliferating cells. Relative to… CONTINUE READING

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