Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice

@article{Garrett2003ExtractsOK,
  title={Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice},
  author={Kennon M. Garrett and Garo P. Basmadjian and Ikhlas A. Khan and Brian T. Schaneberg and Thomas W. Seale},
  journal={Psychopharmacology},
  year={2003},
  volume={170},
  pages={33-41}
}
RationaleKava has been used for centuries by Pacific Islanders for its tranquilizing and sedative effects. [] Key MethodMethodsVarious doses of an ethanolic extract of kava root or diazepam were administered intraperitoneally to BALB/cByJ inbred mice. Behavioral changes were measured in the mirrored chamber avoidance assay and elevated plus-maze assay. Reduced latency to enter and increased time spent in a normally avoided environment operationally defined anxiolysis.
Neuropharmacological studies of Piper auritum Kunth (Piperaceae): antinociceptive and anxiolytic-like effects
TLDR
It is demonstrated for the first time that both organic and aqueous extracts of the leaves of P. auritum possess antinociceptive effect while at higher doses the organic extracts exert a depressant effect on the CNS in mice.
Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
TLDR
Results of the present study indicate that PME possesses anxiolytic-like effects in mice, suggesting sedative and anticonvulsant effects and reducing the stress-induced increase in rectal temperature.
Sedative and anxiolytic effects of the extracts of the leaves of Stachytarpheta cayennensis in mice.
TLDR
Flumazenil, blocked the effect of the leaves of Stachytarpheta cayennensis on rearing, locomotion and elevated plus maze suggesting that GABA receptors are involved in the observed sedative and anxiolytic activities.
Neurobehavioral and toxicological activities of two potentially CNS-acting medicinal plants of Piper genus.
Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells.
TLDR
Results show that kava extract effectively inhibits NE-mediated intracellular calcium influx in H1299 cells, potentially through antagonizing β-AR signaling, and suggests a novel mechanism through which kava and its ingredients potentially offer the anxiolytic and cancer-preventive activity.
Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism
TLDR
This study characterised the functional properties of the major anxiolytic kavalactone, kavain at human recombinant α1β2, β2γ2L, αxβ2γ 2L and α4β2δ GABAARs expressed in Xenopus oocytes using the two-electrode voltage clamp technique, and presents the first experimental evidence in support of a direct interaction between a kvalactone and GABA ARs.
Kavalactones from Kava (Piper methysticum) root extract as modulators of recombinant human glycine receptors
TLDR
Overall, kavalactones exert a moderate inhibitory effect on the human α1 glycine receptor with DL-kavain being the most potent constituent.
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