Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice

@article{Garrett2003ExtractsOK,
  title={Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice},
  author={K. Garrett and G. Basmadjian and I. Khan and B. Schaneberg and T. Seale},
  journal={Psychopharmacology},
  year={2003},
  volume={170},
  pages={33-41}
}
RationaleKava has been used for centuries by Pacific Islanders for its tranquilizing and sedative effects. [...] Key MethodMethodsVarious doses of an ethanolic extract of kava root or diazepam were administered intraperitoneally to BALB/cByJ inbred mice. Behavioral changes were measured in the mirrored chamber avoidance assay and elevated plus-maze assay. Reduced latency to enter and increased time spent in a normally avoided environment operationally defined anxiolysis.Expand
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