Extracts of Devil's Club (Oplopanax horridus) Exert Therapeutic Efficacy in Experimental Models of Acute Myeloid Leukemia

  title={Extracts of Devil's Club (Oplopanax horridus) Exert Therapeutic Efficacy in Experimental Models of Acute Myeloid Leukemia},
  author={Colin M. Mcgill and Estefania J Alba-Rodriguez and Shuo Li and Charles Benson and Regina M Ondrasik and Lindsey N. Fisher and David F. Claxton and Brian M Barth},
  journal={Phytotherapy Research},
  pages={1308 - 1314}
Acute myeloid leukemia (AML) is a group of hematological malignancies defined by expanded clonal populations of immature progenitors (blasts) of myeloid phenotype in blood and bone marrow. Given a typical poor prognostic outlook, there is great need for novel agents with anti‐AML activity. Devil's club (Oplopanax horridus) is one of the most significant medicinal plants used among the indigenous people of Southeast Alaska and the coastal Pacific Northwest, with different linguistic groups… 
Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia
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Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound
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Therapeutic Effect of Blueberry Extracts for Acute Myeloid Leukemia.
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Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
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Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Derivatives
Six polyynes OH-1~6, some of which are occur naturally in acetylated form, had been isolated and identified from the root bark of Oplopanax horridus (Devil’s Club), a natural dietary supplement and medicinal plant in North America, and their anti-proliferation activity was evaluated.
Bioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development
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Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia.
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Inhibition of human ovarian cancer cell lines by devil's club Oplopanax horridus.
Identification of potential anticancer compounds from Oplopanax horridus.
Improving anticancer activities of Oplopanax horridus root bark extract by removing water‐soluble components
Data from this study suggested that the 70% and 100% ethanol fractions are active antiproliferative fractions and that induction of apoptosis is the mechanism involved in the antiprolifierative effect observed.
Chemical and pharmacological studies of Oplopanax horridus, a North American botanical
The research status in the botany, phytochemistry, and pharmacology of OH is summarized, focusing more on the anticancer effects of OH and the involved mechanisms of action.
Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.
Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club, a medicinal plant of North America, and all the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity.
Effects of Oplopanax horridus on human colorectal cancer cells.
The results showed that OhE had potential antiproliferative effects on human colorectal cancer cells, and the active components are enriched in the OhF4 and OhF5 fractions.
Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus.
A pilot study in which blood glucose levels were carefully monitored in an insulin- dependent diabetic patient, a newly diagnosed non-insulin-dependent diabetic, and two healthy adults while they drank devil's club tea does not show any hypoglycemic effect of devil'sClub tea.
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Activation of JAK-STAT signaling via MPLW515L is an important pathogenetic event in patients with JAK2V617F-negative MF, including extramedullary hematopoiesis, splenomegaly, and megakaryocytic proliferation.
Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
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