Extractive alkylation of 6-mercaptopurine and determination in plasma by gas chromatography-mass spectrometry.

Abstract

An analytical procedure was developed for the determination of 6-mercaptopurine in plasma. Owing to the polar character and low plasma concentration of the compound, extraction and derivatization was carried out directly from the plasma sample by extractive alkylation. Determination was made using gas chromatography-mass spectrometry with multiple-ion… (More)

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@article{Floberg1981ExtractiveAO, title={Extractive alkylation of 6-mercaptopurine and determination in plasma by gas chromatography-mass spectrometry.}, author={S Floberg and Paal Hartvig and B. Lindstr{\"o}m and G L{\"o}nner-Holm and B. G. Odlind}, journal={Journal of chromatography}, year={1981}, volume={225 1}, pages={73-81} }