Extraction of near-field fluorescence from composite signals to provide high resolution images of glial cells.

@article{Doyle2001ExtractionON,
  title={Extraction of near-field fluorescence from composite signals to provide high resolution images of glial cells.},
  author={Robert Thomas Doyle and M J Szulzcewski and Philip Haydon},
  journal={Biophysical journal},
  year={2001},
  volume={80 5},
  pages={2477-82}
}
The subdiffraction optical resolution that can be achieved using near-field optical microscopy has the potential to permit new approaches and insights into subcellular function and molecular dynamics. Despite the potential of this technology, it has been difficult to apply to cellular samples. One significant problem is that sample thickness causes the optical information to be comprised of a composite signal containing both near- and far-field fluorescence. To overcome this issue we have… CONTINUE READING