Extraction of hydrophobic species into a water-soluble synthetic receptor.

@article{Hooley2007ExtractionOH,
  title={Extraction of hydrophobic species into a water-soluble synthetic receptor.},
  author={Richard J Hooley and Hillary J Van Anda and Julius Rebek},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 44},
  pages={13464-73}
}
A deep, water-soluble cavitand extracts a variety of neutral hydrophobic species into its cavity. Flexible species such as n-alkanes tumble rapidly on the NMR time scale inside the cavity, but this motion is slowed for bulkier guests. Long, rigid guests such as p-substituted aromatics are either static or only tumble at elevated temperatures via flexing motions of the cavitand. Strong selectivity in recognition of long rigid guests is seen. The binding of neutral guests occurs via the classical… CONTINUE READING