Extraction and measurement of pamidronate from bone samples using automated pre-column derivatization, high-performance liquid chromatography and fluorescence detection.

@article{King1996ExtractionAM,
  title={Extraction and measurement of pamidronate from bone samples using automated pre-column derivatization, high-performance liquid chromatography and fluorescence detection.},
  author={Lynne King and Reinhold Vieth},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1996},
  volume={678 2},
  pages={325-30}
}
A method for the determination of 3-amino-1-hydroxylpropylidene-1, 1-bisphosphonic acid (pamidronate) in bone samples is described. This method combines and modifies parts of previous procedures. Pamidronate is extracted from finely ground bone with dilute hydrochloric acid. Amine-containing contaminants are removed by co-precipitation of pamidronate with… CONTINUE READING