Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies

@inproceedings{Kalb2011ExtractionAI,
  title={Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies},
  author={Suzanne R. Kalb and Wanda I Santana and Isin N. Geren and Consuelo Garcia-Rodriguez and Jianlong Lou and Theresa J. Smith and James D Marks and L. A. Smith and James L. Pirkle and John R. Barr},
  booktitle={BMC Biochemistry},
  year={2011}
}
Botulism is caused by botulinum neurotoxins (BoNTs), extremely toxic proteins which can induce respiratory failure leading to long-term intensive care or death. Treatment for botulism includes administration of antitoxins, which must be administered early in the course of the intoxication; therefore, rapid determination of human exposure to BoNT is an important public health goal. In previous work, our laboratory reported on Endopep-MS, a mass spectrometry-based activity method for detecting… CONTINUE READING
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The use of Endopep-MS to detect multiple subtypes of botulinum neurotoxins

  • SR Kalb, TJ Smith, +7 authors JL Pirkle
  • A, B, E, and F. International Journal of Mass…
  • 2008
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The use of Endopep - MS to detect multiple subtypes of botulinum neurotoxins A , B , E , and F

  • Kalb, TJ Smith, +7 authors JL Pirkle
  • PLoS ONE
  • 2009

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