Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples

@inproceedings{United2013ExtractionAR,
  title={Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples},
  author={He United},
  year={2013}
}
A rapid, sensitive, selective and validated reverse phase high-performance liquid chromatography(RP-HPLC) method for the estimation of paclitaxel in micro-sample of rat plasma and in culture of cancer cells was performed in this study. The mobile phase consisted of an optimized mixture of methanol:water: trifluroacetic acid(80: 20: 0.1, v/v/v). Column elution at a flow rate of 1 mL/minute with UV detection at 225 nm at room temperature was used. The RP-HPLC method was successfully applied for… CONTINUE READING