Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

@article{Kalb2009ExtractionAI,
  title={Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies},
  author={Suzanne R. Kalb and Jianlong Lou and Consuelo Garcia-Rodriguez and Isin N. Geren and Theresa J. Smith and Hercules Moura and James D Marks and L. A. Smith and James L. Pirkle and John R. Barr},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={717 - 766}
}
Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing death or respiratory failure leading to long-term intensive care. Treatment includes serotype-specific antitoxins, which must be administered early in the course of the intoxication. Rapidly determining human exposure to BoNT is an important public health goal. In previous work, our laboratory focused on developing Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating… CONTINUE READING

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