Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae)
@article{Krengel2019ExtractionAC, title={Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae)}, author={Felix Krengel and Marco V. Mijangos and Marisol Reyes-Lezama and Ricardo Reyes‐Chilpa}, journal={Chemistry \& Biodiversity}, year={2019}, volume={16} }
Several species from the Apocynaceae family, such as Tabernanthe iboga, Voacanga africana, and many Tabernaemontana species, produce ibogan type alkaloids, some of which present antiaddictive properties. In this study, we used gas chromatography/mass spectrometry (GC/MS) to examine the efficiency of methanol, acetone, ethyl acetate, dichloromethane, chloroform, and hydrochloric acid in extracting the antiaddictive compounds coronaridine, ibogamine, voacangine, and ibogaine (altogether the CIVI…
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References
SHOWING 1-10 OF 22 REFERENCES
Extraction Studies of Tabernanthe Iboga and Voacanga Africana
- ChemistryNatural product letters
- 2002
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it, and an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammonia, and was successfully applied to related alkaloidal from Voacanga africana bark.
Volume, value and floristic diversity of Gabon׳s medicinal plant markets.
- MedicineJournal of ethnopharmacology
- 2014
Alkaloide aus Conopharyngia durissima STAPF Isovoacangin, Conopharyngin, Conodurin und Conoduramin
- Chemistry
- 1959
One known and four new alkaloids have been isolated from C. durissima STAPF. Isovoacangine (VII) (first isolated from Stemmadenia), conopharyngine (VIII), and possibly also Alkaloid E are monomeric…
Recent synthetic applications of the dealkoxycarbonylation reaction. Part 1. Dealkoxycarbonylations of malonate esters
- Chemistry
- 2007
The purpose of this review is to update (publications from 1981 to mid 2006) the synthetic applications of dealkoxycarbonylations of malonate esters, β-keto esters (and related esters with…
Recent synthetic applications of the dealkoxycarbonylation reaction. Part 2. Dealkoxycarbonylations of β-keto esters, α-cyanoesters and related analogues
- Chemistry
- 2007
In Part 2, the synthetic applications of dealkoxycarbonylations of β-keto esters, α- cyano esters and related activated esters will be reviewed for the period 1981 to the middle of 2006. In Part 1,…
Bwiti: An Ethnography of the Religious Imagination in Africa
- Sociology
- 1982
The Description for this book, Bwiti: An Ethnography of the Religious Imagination in Africa, will be forthcoming.
MASTER’S THESIS
- Computer Science
- 2004
The author of this thesis aimed at investigating the positive and negative effects of using social media through collecting the users' experiences and professionals' viewpoints, and identified other practical effects and aspects of social media.
US Pat
- 1 2,813,873
- 1957
Iboga Root: Dynamics of Iboga’s African Origins and Modern Medical Use
- ‘Herbal Gram’, American Botanical Council
- 2016