Extraction Studies of Tabernanthe Iboga and Voacanga Africana

  title={Extraction Studies of Tabernanthe Iboga and Voacanga Africana},
  author={Christopher W. Jenks},
  journal={Natural Product Letters},
  pages={71 - 76}
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. Ibogaine is used experimentally to interrupt drug addiction and allow therapeutic intervention, but is currently unaffordable to doctors in less economically developed countries. To meet this need, an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammonia, and was successfully applied to related alkaloids from… 

Quantitative Evaluation of a Mexican and a Ghanaian Tabernaemontana Species as Alternatives to Voacanga africana for the Production of Antiaddictive Ibogan Type Alkaloids

The results suggest that T. crassa could be used to produce conopharyngine and ibogaline, two compounds with the same basic skeletal structure and possibly similar antiaddictive properties as ibogaine.

Taberdines L and M, two new alkaloids from Tabernaemontana divaricata

Two new alkaloids, taberdines L (1) and M (2) were isolated from the twigs and leaves of Tabernaemontana divaricata and their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation.

Metabolite Profiling of Anti‐Addictive Alkaloids from Four Mexican Tabernaemontana Species and the Entheogenic African Shrub Tabernanthe iboga (Apocynaceae)

Comparisons of the alkaloid profiles of the root and stem barks of four Mexican Tabernaemontana species with the root bark of the entheogenic African shrub Tabernanthe iboga illustrate the phytochemical proximity between both genera and confirm previous suggestions that MexicanTabernaenana species are viable sources of anti‐addictive compounds.

Chemistry and biology of the genus Voacanga

An exhaustive survey of the literature revealed that indole alkaoids and steroids constitute the major classes of phytoconstituents of this genus.

Quantification of Anti‐Addictive Alkaloids Ibogaine and Voacangine in In Vivo‐ and In Vitro‐Grown Plants of Two Mexican Tabernaemontana Species

It was concluded that T. alba and T. arborea are potentially viable sources of ibogaine and voacangine, and that these MIAs can be produced through somatic embryogenesis and whole plant regeneration of T.Alba.

Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae)

The findings facilitate and improve both the qualitative and quantitative analysis of CIVI‐complex‐containing plant material, as well as outlining a viable method for the bulk production of these scientifically and pharmaceutically important substances from Mexican Tabernaemontana species.

Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub.

The tissue distribution of ibogaine and noribogaine, the main metabolite of ibogsaine, in a 48-year-old Caucasian male found dead at his home after a poisoning involving the ingestion of root bark from the shrub Tabernanthe iboga is reported.

[Chemical and DNA analyses for the products of a psychoactive plant, Voacanga africana].

A simultaneous analytical method was developed using LC/MS for the voacanga alkaloids including ibogaine and tabersonine in the commercial products of V. africana to investigate the trend of such a non-controlled psychotropic plant of abuse.

Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review

The pharmacology of ihogaine is quite complex, affecting many different neurotransmitter systems simultaneously, however, it has been found that this drug has anti-addictive efFecls.

Studies on the Antidepressant Effect of Root Bark Extract of Voacanga africana in Murine Models

The extract of Voacanga africana possesses antidepressant and sedative activities thus confirming its use in the treatment of psychiatric disorders in folk medicine.



Bwiti: An Ethnography of the Religious Imagination in Africa

The Description for this book, Bwiti: An Ethnography of the Religious Imagination in Africa, will be forthcoming.

The alkaloids of Tabernanthe iboga

  • Paszek and W.I. Taylor
  • 1958

Notes- Alkaloids from Apocynaceae II. Ibogaline, A New Alkaloid From Tabernanthe Iboga Baill

A healing journey.

The Healing Journey, pp. 174–228

  • Pantheon Books, Div. Random
  • 1973