Extraction Studies of Tabernanthe Iboga and Voacanga Africana

@article{Jenks2002ExtractionSO,
  title={Extraction Studies of Tabernanthe Iboga and Voacanga Africana},
  author={Christopher W. Jenks},
  journal={Natural Product Letters},
  year={2002},
  volume={16},
  pages={71 - 76}
}
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. Ibogaine is used experimentally to interrupt drug addiction and allow therapeutic intervention, but is currently unaffordable to doctors in less economically developed countries. To meet this need, an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammonia, and was successfully applied to related alkaloids from… 

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Two new alkaloids, taberdines L (1) and M (2) were isolated from the twigs and leaves of Tabernaemontana divaricata and their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation.

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Studies on the Antidepressant Effect of Root Bark Extract of Voacanga africana in Murine Models

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The extract of Voacanga africana possesses antidepressant and sedative activities thus confirming its use in the treatment of psychiatric disorders in folk medicine.

References

SHOWING 1-10 OF 22 REFERENCES

Bwiti: An Ethnography of the Religious Imagination in Africa

The Description for this book, Bwiti: An Ethnography of the Religious Imagination in Africa, will be forthcoming.

The alkaloids of Tabernanthe iboga

  • Paszek and W.I. Taylor
  • 1958

Notes- Alkaloids from Apocynaceae II. Ibogaline, A New Alkaloid From Tabernanthe Iboga Baill

A healing journey.

The Healing Journey, pp. 174–228

  • Pantheon Books, Div. Random
  • 1973