Extracting protein alignment models from the sequence database.

@article{Neuwald1997ExtractingPA,
  title={Extracting protein alignment models from the sequence database.},
  author={Andrew F. Neuwald and Jun S. Liu and David J. Lipman and Charles E. Lawrence},
  journal={Nucleic acids research},
  year={1997},
  volume={25 9},
  pages={1665-77}
}
Biologists often gain structural and functional insights into a protein sequence by constructing a multiple alignment model of the family. Here a program called Probe fully automates this process of model construction starting from a single sequence. Central to this program is a powerful new method to locate and align only those, often subtly, conserved patterns essential to the family as a whole. When applied to randomly chosen proteins, Probe found on average about four times as many… CONTINUE READING

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