Extracting drug mechanism and pharmacodynamic information from clinical electroencephalographic data using generalised semi-linear canonical correlation analysis.

@article{Brain2014ExtractingDM,
  title={Extracting drug mechanism and pharmacodynamic information from clinical electroencephalographic data using generalised semi-linear canonical correlation analysis.},
  author={P. Brain and F. Strimenopoulou and A. Diukova and E. Berry and A. Jolly and J. Hall and R. Wise and M. Ivarsson and F. Wilson},
  journal={Physiological measurement},
  year={2014},
  volume={35 12},
  pages={
          2459-74
        }
}
Conventional analysis of clinical resting electroencephalography (EEG) recordings typically involves assessment of spectral power in pre-defined frequency bands at specific electrodes. EEG is a potentially useful technique in drug development for measuring the pharmacodynamic (PD) effects of a centrally acting compound and hence to assess the likelihood of success of a novel drug based on pharmacokinetic-pharmacodynamic (PK-PD) principles. However, the need to define the electrodes and spectral… Expand
2 Citations
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References

SHOWING 1-10 OF 29 REFERENCES
Guidelines for the Recording and Evaluation of Pharmaco-EEG Data in Man: The International Pharmaco-EEG Society (IPEG)
TLDR
The present updated guidelines reflect the consensus of a global panel of EEG experts and are intended to assist investigators using pharmaco-EEG in clinical research, by providing clear and concise recommendations and thereby enabling standardisation of methodology and facilitating comparability of data across laboratories. Expand
Application of semilinear canonical correlation to the measurement of opioid drug effect
TLDR
This extraction was performed optimally using a new statistical technique, semilinear canonical correlation, and the components of the EEG that were nearly maximally correlated with plasma drug concentration were found, based on a standard pharmacokinetic-pharmacodynamic model. Expand
Generalized Semilinear Canonical Correlation Analysis Applied to the Analysis of Electroencephalogram (EEG) Data
Semilinear canonical correlation analysis (SLCCA) is a technique developed by Gregg, Varvel, and Schafer to combine the powers in an electroencephalogram (EEG) power spectrum at each time point. ThisExpand
Using fMRI to Quantify the Time Dependence of Remifentanil Analgesia in the Human Brain
TLDR
This work has successfully measured, for the first time using fMRI, temporal pharmacological parameters for a CNS-active drug based on its effect on task-related activity in a specific brain region, and characteristic times agreed with the observed drug-induced analgesia and previous pharmacokinetic–pharmacodynamic measurements for remifentanil. Expand
Validation of the Alfentanil Canonical Univariate Parameter as a Measure of Opioid Effect on the Electroencephalogram
TLDR
A new statistical method, semilinear canonical correlation, has been used to construct a new EEG parameter (a certain combination of the powers in the EEG power spectrum) that correlates maximally with the concentration of alfentanil at the effect site. Expand
Can pharmaco-electroencephalography help improve survival of central nervous system drugs in early clinical development?
TLDR
A key finding was that lack of standardisation reduces the value of data pooling and meta-analyses and renders assessment of translatability difficult, limiting utility in all but simple cases. Expand
Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil.
TLDR
Fentanyl and sufentanil have similar pharmacodynamic profiles, the former being 12 times more potent than the latter, according to the electroencephalogram. Expand
Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects
TLDR
Zolpidem reduced saccadic peak velocity, adaptive tracking performance, electroencephalogram (EEG) alpha power and visual analogue scale (VAS) alertness score and increased body sway, EEG beta power and VAS ‘feeling high’ and central nervous system effects normalised more rapidly than the decrease of plasma concentrations. Expand
Dose-Dependent EEG Effects of Zolpidem Provide Evidence for GABAA Receptor Subtype Selectivity in Vivo
TLDR
The mechanism-based PK/PD model is able to describe and explain the observed dose-dependent EEG effects of zolpidem and suggests the subtype selectivity of zOLpidem in vivo. Expand
Pharmacokinetic-pharmacodynamic modeling of opioids.
  • J. Lötsch
  • Medicine
  • Journal of pain and symptom management
  • 2005
The effects of opioids usually parallel the plasma concentrations but with a temporal shift. This temporal shift differs between opioids. It is small with alfentanil or remifentanil and very longExpand
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