Extracting Biological Significant Subnetworks from Protein-Protein Interactions Induced by Differentially Expressed Genes of HIV-1 Vpr Variants

  title={Extracting Biological Significant Subnetworks from Protein-Protein Interactions Induced by Differentially Expressed Genes of HIV-1 Vpr Variants},
  author={Bandana Barman and A. Mukhopadhyay},
  journal={Int. J. Syst. Dyn. Appl.},
Identification of protein interaction network is very important to find the cell signaling pathway for a particular disease. The authors have found the differentially expressed genes between two sample groups of HIV-1. Samples are wild type HIV-1 Vpr and HIV-1 mutant Vpr. They did statistical t-test and found false discovery rate FDR to identify the genes increased in expression up-regulated or decreased in expression down-regulated. In the test, the authors have computed q-values of test to… 
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