Extracting β-amyloid from Alzheimer ’ s disease


T he amyloid hypothesis of Alzheimer’s disease (AD) posits that extracellular plaques comprised of the β-amyloid (Aβ) peptide are a root cause of neuronal loss in AD (1). To date, three therapeutic strategies targeting Aβ have been used: (i) inhibiting the production of Aβ, (ii) inhibiting the oligomerization of Aβ, and (iii) promoting the clearance and/or… (More)

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